Study of the Evolution of the Osteoarthritis Pathology and the Mechanical Properties of Cartilage in a Spontaneous Osteoarthritis Model in the Dunkin-hartley Guinea Pigs

s / Osteoarthritis and Cartilage 25 (2017) S76eS444 S315 When histological items were analyzed individually, it appears that the structure of the cartilage and the proteoglycan content were better correlated with the instantaneous modulus of the femoral condyle (r 1⁄4 0.58, < 0.0001; r1⁄4 0.517, p < 0.0001) thanwith other items. At the tibial plateaus, the strongest associations were found between the items cartilage structure and integrity of tidemark and the young modulus (r 1⁄4 0.435, p 1⁄4 0.0014; r 1⁄4 0.433, p 1⁄4 0, 0015). Conversely, a significantly negative correlation was also observed between the global histological score and OA cartilage thickness (condyle: r 1⁄4 0.346, p 1⁄4 0.009; plateau: r 1⁄4 0.273, p 1⁄4 0.045). Shoulder and Hip OA-like Changes for Obese and Chow Animals. Group Shoulder Joint Hip Joint Humerus Scapula Synovitis Femur Acetabulum Synovitis Chow 2 (2e14) e 0 (0e4) 3 (2e13) 4 (0e6) 0 (0e1) DIO 2 (2e14) 0 (0e14) 0 (0e2) 2 (0e14) 2 (0e14) 0 (0e1)